Clopidogrel + Omeprazole = ???

Omeprazole inhibits CYP2C19 which "reduces the pharmacological activity of [clopidogrel] if given concomitantly or if given 12 hours apart.".

Following drugs chould not be used in combination with clopidogrel:-

esomeprazole,

cimetidine,

fluconazole,

ketoconazole,

voriconazole,

etravirine,

felbamate,

fluoxetine,

fluvoxamine, and

ticlopidine.

FDA suggested that patients who need an acid reducer should switch to "antacids (such as Maalox or Mylanta) and most acid reducers, such as Zantac (ranitidine), Pepcid (famotidine), or Axid (nizatidine).

reference:

http://www.medpagetoday.com/PublicHealthPolicy/PublicHealth/17058?utm_source=breaking-news&utm_medium=email&utm_campaign=breaking-news