hypersensitive airway aka bronchial asthma prevalence increasing worldwide especially amongst children.
environment vs genetic factors blamed for the rise.
various stimuli (allergen) can trigger bronchospasm of the hypersensitive airway.
May 5 annually is World Asthma Day
This year theme is " YOU CAN CONTROL YOUR ASTHMA"
lastest GINA guidelines 2008 showed the following:-
replacing the following, found in their GINA 2002 guidelines
reference:-
1) http://en.wikipedia.org/wiki/Asthma
2) http://www.who.int/respiratory/asthma/en/
3) http://www.nhlbi.nih.gov/health/public/lung/index.htm#asthma
4) http://www.nationalasthma.org.au/cms/index.php
5) http://www.nationalasthma.org.au/content/view/249/639/
6) http://www.asthma.org.uk/
7) http://www.ginasthma.com/Guidelineitem.asp??l1=2&l2=1&intId=60
8) http://www.patient.co.uk/showdoc/40000622/
1 comment:
Please pass this info along to all of your friends and family.
Ozone-friendly inhalers could face early demise
http://www.journalgazette.net/article/20090330/BIZ/303309942/1031/BIZ
Benefits vague, problems clear in inhaler ban
http://www.journalgazette.net/article/20090330/BIZ/303309941
Asthma Patients Outraged at Indifference to Problems with New Inhalers:
http://www.consumeraffairs.com/news04/2009/02/asthma_hfa02.html
Olympian Jackie Joyner-Kersee: FDA "Insensitive" to Asthma Patients' Problems:
http://www.consumeraffairs.com/news04/2009/03/asthma_hfa04.html
The number of patient complaints is skyrocketing:
http://www.consumeraffairs.com/health/hfa_inhalers.html
Read the thousands of complaints at this petition:
http://www.ipetitions.com/petition/saveCFCinhalers/signatures.html
Patients at askapatient.com are reporting HFA inhalers as "useless" with a rating of 1.2 on
a scale of 1 to 5 with 5 being the best and 1 being the worst:
http://www.askapatient.com/viewrating.asp?drug=20503&name=PROVENTIL-HFA
You can only wonder if the FDA is trying to kill asthmatics:
http://www.opednews.com/populum/diarypage.php?did=11627
Also worth mentioning from the FDA website is the fact that a manufacturer of one of the HFA inhalers admits in it's own new drug application to the FDA that it's HFA based albuterol is less safe and effective than it's CFC based albuterol:
http://www.fda.gov/cder/foi/nda/2001/20-983_Ventolin-HFA_medr_P1.pdf
These quotes taken directly from the new drug application for Ventolin HFA.
"In the multiple dose adolescent and adult studies, albuterol HFA showed a numerically smaller improvement in FEV1 than was seen with albuterol CFC"
"There was other evidence that the HFA formulation delivers a lower/less effective dose on a per acutation basis than the CFC product. In the single dose, dose ranging study in adults, and in the single dose methacholine challenge study in adults one and two acutations of albuterol CFC were statistically indistinguishable in terms of effect, whereas significant differences were seen between one and two acutations of albuterol HFA. Finally, the combined adolescent/adult studies showed that the HFA formulation had a longer median time to onset of effect(4.2-9.6 minutes versus 3.6-4.2 minutes), had a shorter duration of effect(1.55-3.30 hours versus 2.29 - 3.69 hours), and was associated with more albuterol 'back up' use than the CFC formulation."
"We note that in the two 12 week clinical trials in adolescents and adults, Ventolin HFA Inhalation Aerosol consistently showed a smaller effect size than Ventolin CFC Inhalation Aerosol"
"Because it is expected that many physicians will prescribe Ventolin HFA Inhalation Aerosol for patients who have previously used the CFC formulation, it would be appropriate to include some description of the relative effectiveness of these two formulations in the product label."
"Unfavorable changes in physical examinations were observed in the ears, nose, and throat category as follows: 8% placebo HFA; 13% albuterol HFA; and 5% albuterol CFC."
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